Electrostatic Control and Chloride Regulation of the Fast Gating of ClC-0 Chloride Channels

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Electrostatic Control and Chloride Regulation of the Fast Gating of ClC-0 Chloride Channels

The opening and closing of chloride (Cl-) channels in the ClC family are thought to tightly couple to ion permeation through the channel pore. In the prototype channel of the family, the ClC-0 channel from the Torpedo electric organ, the opening-closing of the pore in the millisecond time range known as "fast gating" is regulated by both external and internal Cl- ions. Although the external Cl-...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 2003

ISSN: 1540-7748,0022-1295

DOI: 10.1085/jgp.200308846